Effects of cyproterone acetate on growth and androgen metabolism of rat ventral prostate transplants.

Cyproterone acetate (CA0 (10 or 20 mg kg-1 daily for 5 days) injected into castrate rats supplemented with testosterone propionate (TP) caused a significant decrease in ventral prostate weights in situ; no inhibitory effects were noted in transplant weights. CA failed to significantly inhibit DNA in either the in situ prostate or transplant, but his anti-androgen caused a significant decrease in the formation of 3H-dihydrotestosterone and 3H-androstanediol from radioactive testosterone in the in situ organ. Histologically, CA caused a decrease in epithelial cell secretory activity.