Thomson John A, Gray Christina E, Teasdale Graham M
University Department of Medicine, Glasgow Royal Infirmary, Glasgow, Scotland G4 0SF, UK.
Neurosurgery. 2002 Jan;50(1):36-9; discussion 39-40. doi: 10.1097/00006123-200201000-00007.
The long-term results of transsphenoidal surgery for microprolactinoma, with particular reference to the question of permanence of relapse of hyperprolactinemia after biochemical cure, are examined.
Patients whose operations were performed in the city of Glasgow, Scotland, by one neurosurgeon (GMT) have been followed up for between 15 and 21 years after surgery was performed.
Of a cohort of 44 patients with confirmed microprolactinoma at the time of surgery, 8 patients (18.2%) who experienced recurrent hyperprolactinemia postoperatively continued to be monitored. Selective hypophysectomy resulted in normal prolactin levels in all patients initially. Relapse occurred at 2 to 10 years (mean, 5.3 yr) postoperatively, but was permanent in only two patients (4.5%). Of the remaining six patients (13.6%), four (9.1%) became normoprolactinemic after 6 or 7 years' recurrence, and two (4.5%) are now only marginally hyperprolactinemic (prolactin >500 but <700 mU/L) at 15 and 18 years after transsphenoidal hypophysectomy.
The recurrence of hyperprolactinemia after transsphenoidal surgery for microprolactinoma is not necessarily a permanent feature and does not inevitably indicate operative failure.
研究经蝶窦手术治疗微泌乳素瘤的长期疗效，特别关注生化治愈后高泌乳素血症复发的持续性问题。
对在苏格兰格拉斯哥市由一位神经外科医生（GMT）实施手术的患者进行了术后15至21年的随访。
在一组手术时确诊为微泌乳素瘤的44例患者中，8例（18.2%）术后出现高泌乳素血症复发，对其继续进行监测。选择性垂体切除术最初使所有患者的泌乳素水平恢复正常。复发发生在术后2至10年（平均5.3年），但仅2例（4.5%）复发为永久性。其余6例（13.6%）中，4例（9.1%）在复发6或7年后泌乳素水平恢复正常，2例（4.5%）在经蝶窦垂体切除术后15年和18年时仅轻度高泌乳素血症（泌乳素>500但<700 mU/L）。
经蝶窦手术治疗微泌乳素瘤后高泌乳素血症的复发不一定是永久性的，也不一定表明手术失败。
