Rice Ann C, Zsoldos Robert, Chen Tao, Wilson Margaret S, Alessandri B, Hamm Robert J, Bullock M Ross
Departments of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298-0631, USA.
Brain Res. 2002 Feb 22;928(1-2):156-9. doi: 10.1016/s0006-8993(01)03299-1.
Moderately head injured patients often suffer long term neurological sequelae. There is no therapy for brain trauma and current treatments aim only to minimize secondary damage. These secondary effects are often triggered by the inability to re-establish ionic homeostasis after injury, due to large energy demands. Recent reports have demonstrated that neurons are capable of utilizing lactate as an energy source, thus this report examines the usefulness of lactate administration in the attenuation of behavioural deficits following a moderate brain injury. Lactate infusion (i.v.) was started 30 min after lateral fluid percussion injury and continued for 3 h. Cognitive deficits were determined using the Morris water maze. Lactate infused injured animals demonstrated significantly less cognitive deficits than saline infused injured animals. Thus, lactate infusion attenuated the cognitive deficits normally observed in this model, and therefore may provide moderately head injured patients with a treatment to help ameliorate the sequelae.
中度颅脑损伤患者常伴有长期神经后遗症。目前尚无针对脑外伤的治疗方法，现行治疗仅旨在将继发性损伤降至最低。由于能量需求巨大，这些继发性影响往往由损伤后无法重新建立离子稳态引发。最近的报告表明，神经元能够利用乳酸作为能量来源，因此本报告探讨了给予乳酸对减轻中度脑损伤后行为缺陷的作用。在侧方液压冲击伤后30分钟开始静脉输注乳酸，并持续3小时。使用莫里斯水迷宫测定认知缺陷。输注乳酸的损伤动物比输注生理盐水的损伤动物表现出明显更少的认知缺陷。因此，输注乳酸减轻了该模型中通常观察到的认知缺陷，因此可能为中度颅脑损伤患者提供一种有助于改善后遗症的治疗方法。
