丙型肝炎病毒NS3蛋白酶强效抑制剂的溶液合成与固相合成
Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase.
作者信息
Beevers Rebekah, Carr Maria G, Jones Philip S, Jordan Steven, Kay Paul B, Lazell Robert C, Raynham Tony M
机构信息
Department of Chemistry, Roche Discovery Welwyn, 40 Broadwater Road, Welwyn Garden City, AL7 3AY, Hertfordshire, UK.
出版信息
Bioorg Med Chem Lett. 2002 Feb 25;12(4):641-3. doi: 10.1016/s0960-894x(01)00816-2.
Abstract
A versatile route for the synthesis of homochiral alpha-ketoamide analogues of amino acids is described. Incorporation of this functionality into peptide sequences using either solution or solid-phase chemistry resulted in potent inhibitors of the Hepatitis C Virus NS3 proteinase.
摘要
描述了一种合成氨基酸同手性α-酮酰胺类似物的通用途径。使用溶液化学或固相化学将此官能团引入肽序列中，得到了丙型肝炎病毒NS3蛋白酶的有效抑制剂。
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