链霉菌产生的抑制儿茶酚-O-甲基转移酶的新型异黄酮。

New isoflavones, inhibiting catechol-O-methyltransferase, produced by Streptomyces.

作者信息

Chimura H, Sawa T, Kumada Y, Naganawa H, Matsuzaki M

出版信息

J Antibiot (Tokyo). 1975 Sep;28(9):619-26. doi: 10.7164/antibiotics.28.619.

DOI:10.7164/antibiotics.28.619

Abstract

In the screening of catechol-O-methyltransferase inhibitors in streptomyces culture filtrates, three new isoflavones were isolated. Their structures were shown to be 3',5,7-trihydroxy-4',6-dimethoxyisoflavone (I), 3',5,7-trihydroxy-4',8-dimethoxyisoflavone (II), 3',8-dihydroxy-4',6,7-trimethoxyisoflavone (III). I and II inhibited both catechol-O-methyltransferase and dopa decarboxylase, and showed hypotensive action. III was a specific inhibitor of catechol-O-methyltransferase, and showed no hypotensive action.

摘要

在对链霉菌培养滤液中的儿茶酚-O-甲基转移酶抑制剂进行筛选时，分离出了三种新的异黄酮。它们的结构分别为3',5,7-三羟基-4',6-二甲氧基异黄酮（I）、3',5,7-三羟基-4',8-二甲氧基异黄酮（II）、3',8-二羟基-4',6,7-三甲氧基异黄酮（III）。I和II对儿茶酚-O-甲基转移酶和多巴脱羧酶均有抑制作用，并具有降压作用。III是儿茶酚-O-甲基转移酶的特异性抑制剂，无降压作用。