Kuriwaka Rika, Mitsui Takao, Fujiwara Soichiro, Nishida Yoshihiko, Matsumoto Toshio
First Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan.
Eur Neurol. 2002;47(2):85-7. doi: 10.1159/000047958.
Inhalation of organic solvents has long been known to damage various nervous systems, including cerebellum, brainstem, and pyramidal tract. However, little is known about the damage of the dopaminergic system. We report two patients with occupational long-term solvent exposure who developed postural instability without other features of parkinsonism. The concentration of HVA in CSF was decreased and the retropulsion was dramatically improved after the administration of levodopa. These findings indicate that the nigrostriatal dopaminergic neurons were disturbed by chronic solvent exposure, resulting in the loss of postural reflexes.
长期以来，人们都知道吸入有机溶剂会损害包括小脑、脑干和锥体束在内的各种神经系统。然而，对于多巴胺能系统的损害却知之甚少。我们报告了两名长期职业性接触溶剂的患者，他们出现了姿势不稳，但没有帕金森病的其他特征。脑脊液中高香草酸（HVA）的浓度降低，服用左旋多巴后后冲现象得到显著改善。这些发现表明，慢性溶剂暴露扰乱了黑质纹状体多巴胺能神经元，导致姿势反射丧失。
