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A novel hepatocyte nuclear factor-1beta (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes.

作者信息

Carbone I, Cotellessa M, Barella C, Minetti C, Ghiggeri G M, Caridi G, Perfumo F, Lorini R

出版信息

Diabetologia. 2002 Jan;45(1):153-4. doi: 10.1007/s125-002-8258-8.

DOI:10.1007/s125-002-8258-8
PMID:11845237
Abstract
摘要

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A novel hepatocyte nuclear factor-1beta (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes.一个患有肾功能障碍和早发性糖尿病的意大利家庭中发现的一种新型肝细胞核因子-1β(MODY-5)基因突变。
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The transcription factor Myt3 acts as a pro-survival factor in β-cells.转录因子 Myt3 在β细胞中作为一种促生存因子发挥作用。
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