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Int Immunol. 2008 Mar;20(3):413-20. doi: 10.1093/intimm/dxn006. Epub 2008 Jan 21.
2
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Nat Genet. 2008 Feb;40(2):204-10. doi: 10.1038/ng.81. Epub 2008 Jan 20.
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Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes.对非肥胖糖尿病近交系小鼠的CD4 + T细胞进行全基因组微阵列表达分析，确定Cd55（Daf1）和Acadl为1型糖尿病的候选基因。
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Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.通过沉默信号转导环磷酸腺苷反应元件调节因子α和双特异性磷酸酶14的负调控因子来增强胰高血糖素样肽-1诱导的β细胞增殖。
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Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.解偶联蛋白UCP2在细胞介导免疫中的作用：在自身免疫性糖尿病模型中巨噬细胞介导的胰岛炎是如何加速的。
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鼠标糖尿病 QTL 的遗传与分子基础：基因与多态性。

Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms.

机构信息

Departments of Orthopaedic Surgery, Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

出版信息

Curr Genomics. 2008;9(5):324-37. doi: 10.2174/138920208785133253.

DOI:10.2174/138920208785133253
PMID:19471607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2685644/
Abstract

A systematic study has been conducted of all available reports in PubMed and OMIM (Online Mendelian Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic loci (QTL) of diabetes with the main focus on genes and polymorphisms. The major question is, What can the QTL tell us? Specifically, we want to know whether those genome regions differ from other regions in terms of genes relevant to diabetes. Which genes are within those QTL regions, and, among them, which genes have already been linked to diabetes? whether more polymorphisms have been associated with diabetes in the QTL regions than in the non-QTL regions.Our search revealed a total of 9038 genes from 26 type 1 diabetes QTL, which cover 667,096,006 bp of the mouse genomic sequence. On one hand, a large number of candidate genes are in each of these QTL; on the other hand, we found that some obvious candidate genes of QTL have not yet been investigated. Thus, the comprehensive search of candidate genes for known QTL may provide unexpected benefit for identifying QTL genes for diabetes.

摘要

我们系统地研究了 PubMed 和 OMIM（Online Mendelian Inheritance in Man）中所有可用的报告，以检查糖尿病数量遗传位点（QTL）的遗传和分子基础，主要关注基因和多态性。主要问题是，QTL 能告诉我们什么？具体来说，我们想知道这些基因组区域在与糖尿病相关的基因方面是否与其他区域不同。这些 QTL 区域内有哪些基因，其中哪些基因已经与糖尿病有关？与非 QTL 区域相比，QTL 区域中与糖尿病相关的多态性是否更多？我们的搜索总共从 26 个 1 型糖尿病 QTL 中发现了 9038 个基因，涵盖了小鼠基因组序列的 667,096,006 个碱基对。一方面，这些 QTL 中的每一个都有大量的候选基因；另一方面，我们发现一些 QTL 的明显候选基因尚未被研究过。因此，对已知 QTL 的候选基因进行全面搜索可能会为鉴定糖尿病的 QTL 基因提供意想不到的好处。