非小细胞肺癌患者开胸手术时发现的恶性少量胸腔积液：肿瘤切除对预后有益吗？
Malignant minor pleural effusion detected on thoracotomy for patients with non-small cell lung cancer: is tumor resection beneficial for prognosis?
作者信息
Sawabata Noriyoshi, Matsumura Akihide, Motohiro Akira, Osaka Yoshihiko, Gennga Keiichiro, Fukai Shimao, Mori Takashi
机构信息
Division of Surgery, Toneyama National Hospital, Toyonaka, Osaka, Japan.
出版信息
Ann Thorac Surg. 2002 Feb;73(2):412-5. doi: 10.1016/s0003-4975(01)03426-9.
BACKGROUND
This study attempts to clarify the benefit of surgery for non-small cell lung cancer (NSCLC) with malignant minor pleural effusion that is detected at thoracotomy.
METHODS
Records of surgical patients with NSCLC were reviewed, with a definition of minor pleural effusion as less than 300 mL. The patients were divided into three groups as follows: (1) group C consisted of patients who underwent grossly complete resection; group I, patients with incomplete tumor resection; and group E, patients who underwent exploratory thoracotomy only.
RESULTS
There were 196 patients who had minor pleural effusion; of these, 96 (46%) underwent an examination to define the malignancy status of pleural effusion after surgery. In 43 patients (45%), the effusion was found to be malignant. The median survival time and 5-year survival rate, respectively, were 13 months and 9% for group C (n = 11); 34 months and 10% for group I (n = 14; p = 0.3); and 17 months and 0% for group E (n = 18; p = 0.8).
CONCLUSIONS
Tumor resection is not beneficial for the survival of patients with NSCLC who have a minor malignant pleural effusion.
背景
本研究旨在阐明手术对开胸手术时发现的伴有少量恶性胸腔积液的非小细胞肺癌（NSCLC）患者的益处。
方法
回顾了NSCLC手术患者的记录，将少量胸腔积液定义为少于300 mL。患者分为以下三组：（1）C组由接受大体完全切除的患者组成；I组为肿瘤切除不完全的患者；E组为仅接受开胸探查的患者。
结果
有196例患者有少量胸腔积液；其中96例（46%）在术后接受了检查以明确胸腔积液的恶性状态。在43例患者（45%）中，发现积液为恶性。C组（n = 11）的中位生存时间和5年生存率分别为13个月和9%；I组（n = 14；p = 0.3）为34个月和10%；E组（n = 18；p = 0.8）为17个月和0%。
结论
肿瘤切除对伴有少量恶性胸腔积液的NSCLC患者的生存无益。
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