慢性非甾体抗炎药使用者的生活质量：奥美拉唑与米索前列醇效果的比较。

Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol.

作者信息

Yeomans N, Wilson I, Långström G, Hawkey C, Naesdal J, Walan A, Wiklund I

机构信息

Department of Medicine, The University of Melbourne, Western Hospital, Footscray, Australia.

出版信息

Scand J Rheumatol. 2001;30(6):328-34. doi: 10.1080/030097401317148516.

DOI:10.1080/030097401317148516

PMID:11846050

Abstract

OBJECTIVE

To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions.

METHODS

Validated baseline and follow-up QoL questionnaires were completed by 610 patients (healing: after 4/8 weeks; maintenance: after 6 months).

RESULTS

Patients with arthritis being treated with NSAIDs have a poor QoL. Rheumatoid arthritis causes more joint problems and physical mobility limitations than osteoarthritis. Chronic NSAID use causes heartburn and dyspepsia. QoL improved on both treatments (about equally on two general QOL scales), but omeprazole relieved gastrointestinal symptoms more than misoprostol, particularly reflux, abdominal pain and indigestion symptoms. During maintenance, both treatments maintained QoL, but misoprostol induced diarrhoea.

CONCLUSION

QoL in arthritis patients on chronic NSAID treatment is destroyed. Omeprazole is superior to misoprostol for relief and prevention of NSAID-associated gastrointestinal symptoms allowing continued NSAID treatment without compromising the patients' QoL.

摘要

目的

比较奥美拉唑和米索前列醇在愈合期间对慢性非甾体抗炎药（NSAID）使用者合并NSAID相关胃十二指肠病变的生活质量（QoL）的影响，以及奥美拉唑、米索前列醇和安慰剂在维持治疗期间的影响。

方法

610例患者完成了经过验证的基线和随访QoL问卷（愈合：4/8周后；维持：6个月后）。

结果

接受NSAIDs治疗的关节炎患者生活质量较差。类风湿性关节炎比骨关节炎导致更多的关节问题和身体活动受限。长期使用NSAIDs会引起烧心和消化不良。两种治疗方法均可改善生活质量（在两个总体QOL量表上改善程度大致相同），但奥美拉唑比米索前列醇更能缓解胃肠道症状，尤其是反流、腹痛和消化不良症状。在维持治疗期间，两种治疗方法均可维持生活质量，但米索前列醇会引起腹泻。