在遗传变异的赖特-费希尔中性模型下生成样本。

Generating samples under a Wright-Fisher neutral model of genetic variation.

作者信息

Hudson Richard R

机构信息

Department of Ecology and Evolution, University of Chicago, 1101 E. 57th Street, Chicago, IL 60637, USA.

出版信息

Bioinformatics. 2002 Feb;18(2):337-8. doi: 10.1093/bioinformatics/18.2.337.

DOI:10.1093/bioinformatics/18.2.337

PMID:11847089

Abstract

A Monte Carlo computer program is available to generate samples drawn from a population evolving according to a Wright-Fisher neutral model. The program assumes an infinite-sites model of mutation, and allows recombination, gene conversion, symmetric migration among subpopulations, and a variety of demographic histories. The samples produced can be used to investigate the sampling properties of any sample statistic under these neutral models.

摘要

有一个蒙特卡罗计算机程序可用于生成从根据赖特-费希尔中性模型进化的群体中抽取的样本。该程序假定了一个无限位点突变模型，并允许重组、基因转换、亚群体间的对称迁移以及各种人口统计学历史情况。所产生的样本可用于研究在这些中性模型下任何样本统计量的抽样特性。