Lundgren-Eriksson L, Palm A, Ryd W, Warnhammar E, Hultborn R
Department of Radiation Sciences, Oncology, Umeå University, Sweden.
Anticancer Res. 2001 Sep-Oct;21(5):3269-74.
The influence of hypothermia induced by chlorpromazine (10-15 mg/kg given intra-peritoneally) on the survival from radiation and chemotherapy exposure in C57B1-mice, with or without tumour inoculation, was studied.
The mice were exposed to either whole body irradiation (8 Gy), or doxorubicin (15 or 17.5 mg/kg i.p.), or cisplatin (20 mg/kg i. p.) and followed to ensuing death. The control mice maintained a rectal temperature of 38 degres C while those receiving chlorpromazine developed moderate hypothermia of 28 degrees C or 36 degrees C, dependent on the ambient temperature.
Hypothermia of 28 degrees C protected the mice from radiation-induced death and acute doxorubicin toxicity, with males gaining more protection than females. The effects appeared dependent on temperature, not on chlorpromazine. Hypothermia protected the mice from acute cisplatin toxicity and increased the anti-tumour effects in both genders. Chlorpromazine itself did not cause toxicity, neither did it change the natural course of tumour progression.
Hypothermia of 28 degrees C induced by chlorpromazine profoundly reduces radiation, doxorubicin-and cisplatin-induced toxicity in mice with males benefiting more than females. The hypothermia itself, not the chlorpromazine, was responsible for these effects. The anti-neoplastic activity was not compromised; rather, it was enhanced, particularly for cisplatin.
研究了氯丙嗪（腹腔注射10 - 15毫克/千克）诱导的低温对有无肿瘤接种的C57B1小鼠辐射和化疗暴露后存活情况的影响。
将小鼠暴露于全身照射（8戈瑞）、阿霉素（腹腔注射15或17.5毫克/千克）或顺铂（腹腔注射20毫克/千克）下，随后观察至死亡。对照小鼠直肠温度维持在38摄氏度，而接受氯丙嗪的小鼠根据环境温度出现28摄氏度或36摄氏度的中度低温。
28摄氏度的低温可保护小鼠免受辐射诱导的死亡和急性阿霉素毒性，雄性小鼠比雌性小鼠获得更多保护。这些效应似乎取决于温度，而非氯丙嗪。低温可保护小鼠免受急性顺铂毒性，并增强两性的抗肿瘤作用。氯丙嗪本身不会引起毒性，也不会改变肿瘤进展的自然进程。
氯丙嗪诱导的28摄氏度低温可显著降低辐射、阿霉素和顺铂诱导的小鼠毒性，雄性小鼠比雌性小鼠受益更多。这些效应是由低温本身而非氯丙嗪引起的。抗肿瘤活性未受损害；相反，它得到了增强，尤其是对顺铂而言。
