放射治疗与伤口愈合。
Radiotherapy and wound healing.
作者信息
Dormand Emma-Louise, Banwell Paul E, Goodacre Timothy E E
机构信息
Department of Plastic Surgery, Radcliffe Infirmary, Woodstock Road, Oxford, UK.
出版信息
Int Wound J. 2005 Jun;2(2):112-27. doi: 10.1111/j.1742-4801.2005.00079.x.
Abstract
Radiotherapy is an invaluable weapon when treating cancer. However, the deleterious effects of radiation, both immediate and long-term, may have a significant effect on local tissues. Problematic wound healing in radiation-damaged tissue constitutes a major problem that is frequently overlooked during the management of patients who require radiotherapy, or have had radiotherapy in the past. Poor wound healing may lead to chronic ulceration, pain, secondary infection and psychological distress and compromise the outcome of general or reconstructive surgery. We discuss the pathophysiology of poor wound healing following radiotherapy, specific problems for radiation-damaged tissue and potential treatments to improve wound healing of irradiated tissues.
摘要
放射疗法是治疗癌症时的一种宝贵武器。然而，辐射的有害影响，包括即时和长期影响，可能会对局部组织产生重大影响。放射损伤组织中存在的伤口愈合问题是一个主要问题，在需要放疗或过去接受过放疗的患者管理过程中常常被忽视。伤口愈合不良可能导致慢性溃疡、疼痛、继发感染和心理困扰，并影响普通外科手术或重建手术的结果。我们讨论放疗后伤口愈合不良的病理生理学、放射损伤组织的具体问题以及改善受照组织伤口愈合的潜在治疗方法。
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