富含脯氨酸的小分子重复蛋白1A由轴突切断的神经元表达，并促进轴突生长。
Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth.
作者信息
Bonilla Iris E, Tanabe Katsuhisa, Strittmatter Stephen M
机构信息
Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
出版信息
J Neurosci. 2002 Feb 15;22(4):1303-15. doi: 10.1523/JNEUROSCI.22-04-01303.2002.
The ability of neurons to regenerate an axon after injury is determined by both the surrounding environment and factors intrinsic to the damaged neuron. We have used cDNA microarrays to survey those genes induced during successful sciatic nerve regeneration. The small proline-rich repeat protein 1A (SPRR1A) is not detectable in uninjured neurons but is induced by >60-fold after peripheral axonal damage. The protein is localized to injured neurons and axons. sprr1a is one of a group of epithelial differentiation genes, including s100c and p21/waf, that are coinduced in neurons by axotomy. Overexpressed SPRR1A colocalizes with F-actin in membrane ruffles and augments axonal outgrowth on a range of substrates. In axotomized sensory neurons, reduction of SPRR1A function restricts axonal outgrowth. Neuronal SPRR1A may be a significant contributor to successful nerve regeneration.
神经元在损伤后再生轴突的能力取决于周围环境和受损神经元的内在因素。我们使用cDNA微阵列来检测在坐骨神经成功再生过程中诱导表达的那些基因。富含脯氨酸的小重复蛋白1A（SPRR1A）在未受损的神经元中无法检测到，但在外周轴突损伤后诱导表达增加60倍以上。该蛋白定位于受损的神经元和轴突。sprr1a是一组上皮分化基因之一，包括s100c和p21/waf，它们在神经元中由轴突切断共同诱导表达。过表达的SPRR1A与膜皱襞中的F-肌动蛋白共定位，并增强在一系列底物上的轴突生长。在轴突切断的感觉神经元中，SPRR1A功能的降低会限制轴突生长。神经元SPRR1A可能是神经成功再生的一个重要因素。
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