Adil S N, Burney I A, Kakepoto G N, Khurshid M
Department of Pathology, Aga Khan University Hospital, Karachi.
J Pak Med Assoc. 2001 Dec;51(12):443-5.
To complete the data on the demographic features of patients diagnosed to have aplastic anemia at a single institution over a 7.5 years period.
Demographic information was retrieved from the patients medical records retrospectively as well as prospectively of those patients who presented with features of aplastic anaemia. Their diagnosis was confirmed by performing a complete blood count and bone marrow trephine.
One hundred and forty four patients were diagnosed to have aplastic anemia; there were 106 males and 38 females. Their ages ranged from 2 to 75 years, with a median of 17 years, 112 (77.7%) patients were below the age of 30 years. Severe aplastic anemia (SAA) was seen in 74 (51.4%), very severe (VSAA) in 24 (16.7%) and non-severe aplastic anemia (NSAA) in 46 (31.9%) patients. No obvious cause could be established for 74.3%. Thirteen patients admitted using drugs known to cause AA and one was a radiographer (9%). Out of 44 patients tested, 7 (15.9%) were found to have either hepatitis B virus markers or antibody to hepatitis C at the time of diagnosis of AA. However it was difficult to establish a cause and effect relationship with either drugs or viruses.
Aplastic anaemia is found to occur mostly in young males. The most common type was idiopathic severe aplastic anaemia.
完善某单一机构7.5年间诊断为再生障碍性贫血患者的人口统计学特征数据。
回顾性地从患者病历中检索人口统计学信息，并前瞻性地收集那些表现出再生障碍性贫血特征患者的信息。通过进行全血细胞计数和骨髓活检来确诊。
144例患者被诊断为再生障碍性贫血；其中男性106例，女性38例。年龄范围为2至75岁，中位数为17岁，112例（77.7%）患者年龄低于30岁。74例（51.4%）为重型再生障碍性贫血（SAA），24例（16.7%）为极重型（VSAA），46例（31.9%）为非重型再生障碍性贫血（NSAA）。74.3%的患者无法明确病因。13例患者承认使用过已知可导致再生障碍性贫血的药物，1例为放射技师（9%）。在44例接受检测的患者中，7例（15.9%）在再生障碍性贫血诊断时被发现有乙肝病毒标志物或丙肝抗体。然而，很难确定与药物或病毒之间的因果关系。
再生障碍性贫血多见于年轻男性。最常见的类型是特发性重型再生障碍性贫血。
