Ehsan Ayesha, Shah Shahida Amjad Riaz, Ibrahim Tayyaba
Department of Haematology, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan.
J Ayub Med Coll Abbottabad. 2011 Jan-Mar;23(1):102-5.
Acquired aplastic anaemia is a rare disease which results in morbidity and mortality at a young age. This study was carried out to determine the clinical presentation, haematological parameters and association factors of acquired aplastic anaemia in a cohort of Pakistani patients.
This was a cross-sectional study conducted at Haematology Department, Shaikh Zayed Hospital, Lahore over 7 years from June 2000 to July 2007. Eighty-two patients of acquired aplastic anaemia were enrolled in the study by non-probability purposive sampling. Their diagnosis was confirmed by complete blood count, bone marrow aspirate and trephine biopsy. The cohort was classified on the basis of severity and the epidemiological, clinical and haematological parameters were analysed.
Of the 82 enrolled patients of acquired aplastic anaemia, 49 (59.8%) were males and 33 (40.2%) were females. Mean age of the patients was 27.93 +/- 18.7 years with a range of 1-80 years. The male to female ratio was 1.48:1. Bone marrow cellularity was less than 25 % in 31 (38.0%) cases and between 25-30% in 51 (62%) of patients. Most of the cases were clinically severe aplastic anaemia (68%). In 62 (76%) of the cases no association factors predisposing to aplastic anaemia could be identified.
Acquired Aplastic anaemia is a disease of all ages. In the second decade and the elderly predominantly severe clinical stages were seen. Males presented at a younger age while females presented at all ages with a somewhat similar incidence. No association factors of Aplastic Anaemia could be identified in majority of the patients.
获得性再生障碍性贫血是一种罕见疾病，可导致患者在年轻时发病并死亡。本研究旨在确定一组巴基斯坦患者中获得性再生障碍性贫血的临床表现、血液学参数及相关因素。
这是一项横断面研究，于2000年6月至2007年7月在拉合尔谢赫扎耶德医院血液科进行，为期7年。通过非概率目的抽样，82例获得性再生障碍性贫血患者纳入本研究。通过全血细胞计数、骨髓穿刺和活检确诊。根据病情严重程度对该队列进行分类，并分析流行病学、临床和血液学参数。
82例获得性再生障碍性贫血患者中，49例（59.8%）为男性，33例（40.2%）为女性。患者平均年龄为27.93±18.7岁，年龄范围为1 - 80岁。男女比例为1.48:1。31例（38.0%）患者骨髓细胞密度低于25%，51例（62%）患者骨髓细胞密度在25% - 30%之间。大多数病例为临床重型再生障碍性贫血（68%）。62例（76%）病例中未发现导致再生障碍性贫血的相关因素。
获得性再生障碍性贫血是一种全年龄段疾病。在第二个十年及老年患者中，主要表现为严重临床阶段。男性发病年龄较轻，女性各年龄段均有发病，发病率相近。大多数患者未发现再生障碍性贫血的相关因素。
