Iversen E, Pedersen K O
Scand J Clin Lab Invest. 1979 Feb;39(1):7-13. doi: 10.3109/00365517909104933.
The 24 h urinary excretion (dU) of T4 and T3, determined by radioimmunoassays using extraction and separation on Sephadex columns, is higher in men than in women (mean dU-T4 and dU-T3 +/- 2 SD: 2.6 +/- 0.9 vs. 2.2 +/- 1.0 and 2.5 +/- 1.0 vs. 2.0 +/- 0.8 nmol, respectively). The excretion of T3 decreases with age, but expressed relatively to dU-creatinine there is no effect of age and sex. Children have increased T4 and T3 to creatinine excretion ratios and neonates excrete predominantly T4. Oestrogens, acute salicylate loading and diurnal variation yielded results, which were at variance with the hypothesis that dU-T4 and dU-T3 mirror corresponding free hormone concentrations in serum, and there was only a weal positive correlation to total serum hormones in thyrotoxicosis as well. General clinical use of urine T4 and T3 is obviated by poor diagnostic discrimination and inherent analytical and interpretative disadvantages.
采用葡聚糖凝胶柱提取和分离的放射免疫分析法测定，男性T4和T3的24小时尿排泄量（dU）高于女性（平均dU-T4和dU-T3 +/- 2标准差：分别为2.6 +/- 0.9对2.2 +/- 1.0以及2.5 +/- 1.0对2.0 +/- 0.8 nmol）。T3的排泄量随年龄增长而降低，但相对于dU-肌酐而言，年龄和性别并无影响。儿童的T4和T3与肌酐排泄率升高，新生儿则主要排泄T4。雌激素、急性水杨酸盐负荷和昼夜变化所产生的结果与dU-T4和dU-T3反映血清中相应游离激素浓度这一假设不符，而且在甲状腺毒症中与血清总激素也仅有微弱的正相关。尿T4和T3在一般临床应用中因诊断鉴别能力差以及固有的分析和解释缺陷而未被采用。
