Rogowski P, Faber J, Kirkegaard C, Lundsteen M, Poulsen D, Siersbaek-Nielsen K
Acta Endocrinol (Copenh). 1978 Oct;89(2):276-83. doi: 10.1530/acta.0.0890276.
The urinary excretion and serum levels of thyroxine (T4), triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3) was estimated in a longitudinal study of human newborns. The maternal and cord blood was also studied. Neonatal renal function was evaluated using endogenous creatinine clearance. In cord blood serum T3 was found to be lower than in maternal blood, but reverse T3 highly elevated. During the first 5 days of life serum T4 and T3 increased with maximum at 48 and 24 h in contrast to reverse T3 which remained high and then declined rapidly after 4 days. Creatinine clearance during the first 3 days of life increased from 5.3 to 21.9 ml/min/1.73 m2. In the same period the urinary T4 excretion increased from 79 to 281 ng/24 h, urinary T3 excretion from 16 to 44 ng/24 h and urinary reverse T3 from 4 to 15 ng/24 h. The renal excretion of thyroid hormones, corrected for body surface, was decreased compared to adult controls, corresponding to an immature renal function. The lack of ability to excrete thyroid hormones involved primary T3 and reverse T3 suggesting particular immaturity of tubular secretion of these hormones during the neonatal period.
在一项针对人类新生儿的纵向研究中，对甲状腺素（T4）、三碘甲状腺原氨酸（T3）和3,3',5'-三碘甲状腺原氨酸（反式T3）的尿排泄量和血清水平进行了评估。同时也对母体血和脐带血进行了研究。使用内生肌酐清除率评估新生儿肾功能。在脐带血中，发现血清T3低于母体血，但反式T3显著升高。在出生后的前5天，血清T4和T3升高，分别在48小时和24小时达到最大值，而反式T3则保持在较高水平，4天后迅速下降。出生后前3天，肌酐清除率从5.3增加到21.9 ml/min/1.73 m²。在同一时期，尿T4排泄量从79增加到281 ng/24小时，尿T3排泄量从16增加到44 ng/24小时，尿反式T3从4增加到15 ng/24小时。与成年对照组相比，经体表校正后的甲状腺激素肾排泄量减少，这与肾功能不成熟相对应。排泄甲状腺激素能力的缺乏涉及原发性T3和反式T3，这表明在新生儿期这些激素的肾小管分泌特别不成熟。
