视紫红质磷酸化：从终止单光子反应到光感受器暗适应

Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation.

作者信息

Arshavsky Vadim Y

机构信息

Dept of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA.

出版信息

Trends Neurosci. 2002 Mar;25(3):124-6. doi: 10.1016/s0166-2236(00)02094-4.

DOI:10.1016/s0166-2236(00)02094-4

PMID:11852136

Abstract

Rhodopsin phosphorylation has provided one of the first examples of the ubiquitous regulatory pattern of specific kinases downregulating the activity of G-protein-coupled receptors. However, only recently have studies in living animals allowed us to consider the role of rhodopsin phosphorylation in a broader spectrum of visual functions, ranging from the ability of rods to generate reproducible electrical responses to their ability to adapt to darkness after substantial light exposures.

摘要

视紫红质磷酸化是特定激酶下调G蛋白偶联受体活性这种普遍调节模式的首批示例之一。然而，直到最近，对活体动物的研究才使我们能够思考视紫红质磷酸化在更广泛视觉功能中的作用，这些功能从视杆细胞产生可重复电反应的能力，到在大量光照后适应黑暗的能力。