Friis B
Scand J Infect Dis. 1979;11(3):211-7. doi: 10.3109/inf.1979.11.issue-3.07.
The bacteriological effect of chemotherapy against Pseudomonas aeruginosa (Ps.ae.) in lungs of patients with cystic fibrosis is reviewed. During a 5-year period 49 children and adults were treated with 190 courses of different antibiotics. The mucoid strains of Ps.ae. disappeared in 72.0% of the courses in which a combination of tobramycin and carbenicillin was employed. Tobramycin given alone had only bacteriological effect in 26.6% of the courses. Colimycin alone or in combination with carbenicillin had no effect. In 18 patients who received subsequent courses of tobramycin and combination of tobramycin and carbenicillin a significant difference in favour of the combination therapy was found, also in cases with many precipitins against Ps.ae. in serum. In 74.5% of the initially successful courses the patients were recolonized with Ps.ae. within 1 month. No nephrotoxic or ototoxic side effects were demonstrated in spite of the high doses of tobramycin (10 mg/kg/24 h) emmployed and the repeated courses.
本文综述了化疗对囊性纤维化患者肺部铜绿假单胞菌（Ps.ae.）的细菌学效应。在5年期间，49名儿童和成人接受了190个疗程的不同抗生素治疗。在使用妥布霉素和羧苄西林联合治疗的疗程中，72.0%的黏液型Ps.ae.菌株消失。单独使用妥布霉素时，只有26.6%的疗程有细菌学效应。单独使用黏菌素或与羧苄西林联合使用均无效果。在18名接受后续妥布霉素疗程以及妥布霉素与羧苄西林联合疗程的患者中，发现联合治疗具有显著优势，血清中存在许多抗Ps.ae.沉淀素的病例也是如此。在最初成功的疗程中，74.5%的患者在1个月内被Ps.ae.重新定植。尽管使用了高剂量的妥布霉素（10mg/kg/24小时）且进行了重复疗程，但未发现肾毒性或耳毒性副作用。
