氨曲南联合妥布霉素和庆大霉素对囊性纤维化患者铜绿假单胞菌和洋葱伯克霍尔德菌临床分离株的体外活性。
In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis.
作者信息
Bosso J A, Saxon B A, Matsen J M
机构信息
Department of Pharmacy Practice, College of Pharmacy, University of Utah, Salt Lake City 84112.
出版信息
Antimicrob Agents Chemother. 1987 Sep;31(9):1403-5. doi: 10.1128/AAC.31.9.1403.
Abstract
The in vitro activity of aztreonam combined with tobramycin and with gentamicin was assessed in 78 clinical isolates of Pseudomonas aeruginosa and 11 clinical isolates of Pseudomonas cepacia from patients with cystic fibrosis. Synergy was detected in 56.4% of P. aeruginosa isolates and 60% of P. cepacia isolates with the aztreonam-tobramycin combination and in 49.3% of P. aeruginosa isolates and 81.8% of P. cepacia isolates with the aztreonam-gentamicin combination. No antagonism was observed. These combinations merit clinical evaluation in the treatment of patients with cystic fibrosis.
摘要
对78株来自囊性纤维化患者的铜绿假单胞菌临床分离株和11株洋葱伯克霍尔德菌临床分离株，评估了氨曲南联合妥布霉素以及联合庆大霉素的体外活性。氨曲南 - 妥布霉素联合用药时，在56.4%的铜绿假单胞菌分离株和60%的洋葱伯克霍尔德菌分离株中检测到协同作用；氨曲南 - 庆大霉素联合用药时，在49.3%的铜绿假单胞菌分离株和81.8%的洋葱伯克霍尔德菌分离株中检测到协同作用。未观察到拮抗作用。这些联合用药值得在囊性纤维化患者的治疗中进行临床评估。
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