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In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis.氨曲南联合妥布霉素和庆大霉素对囊性纤维化患者铜绿假单胞菌和洋葱伯克霍尔德菌临床分离株的体外活性。
Antimicrob Agents Chemother. 1987 Sep;31(9):1403-5. doi: 10.1128/AAC.31.9.1403.
2
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In vitro activities of combinations of aztreonam, ciprofloxacin, and ceftazidime against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis.氨曲南、环丙沙星和头孢他啶联合用药对囊性纤维化患者铜绿假单胞菌和洋葱伯克霍尔德菌临床分离株的体外活性。
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Diagn Microbiol Infect Dis. 1989 Jul-Aug;12(4):343-9. doi: 10.1016/0732-8893(89)90101-6.
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In vitro activity of amiloride combined with tobramycin against Pseudomonas isolates from patients with cystic fibrosis.氨氯吡咪与妥布霉素联合应用对囊性纤维化患者分离出的铜绿假单胞菌的体外活性。
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7
In vitro evaluation of tobramycin and aztreonam versus Pseudomonas aeruginosa biofilms on cystic fibrosis-derived human airway epithelial cells.体外评价妥布霉素和氨曲南对囊性纤维化来源的人气道上皮细胞上铜绿假单胞菌生物膜的作用。
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Evaluation of the E test for the assessment of synergy of antibiotic combinations against multiresistant Pseudomonas aeruginosa isolates from cystic fibrosis patients.评估E试验在评价针对囊性纤维化患者多重耐药铜绿假单胞菌分离株的抗生素联合协同作用中的应用。
Eur J Clin Microbiol Infect Dis. 2006 Jan;25(1):25-30. doi: 10.1007/s10096-005-0076-9.
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Routine susceptibility testing of four antibiotic combinations for improvement of laboratory guide to therapy of cystic fibrosis infections caused by Pseudomonas aeruginosa.对四种抗生素组合进行常规药敏试验，以完善铜绿假单胞菌引起的囊性纤维化感染治疗的实验室指南。
Antimicrob Agents Chemother. 1995 Nov;39(11):2411-4. doi: 10.1128/AAC.39.11.2411.
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Chloramphenicol resistance in Pseudomonas cepacia because of decreased permeability.洋葱伯克霍尔德菌中由于通透性降低导致的氯霉素耐药性。
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Changing susceptibility of Pseudomonas aeruginosa isolates from cystic fibrosis patients with the clinical use of newer antibiotics.随着新型抗生素在临床中的使用，囊性纤维化患者铜绿假单胞菌分离株的药敏性发生变化。
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8
In vitro activities of combinations of aztreonam, ciprofloxacin, and ceftazidime against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis.氨曲南、环丙沙星和头孢他啶联合用药对囊性纤维化患者铜绿假单胞菌和洋葱伯克霍尔德菌临床分离株的体外活性。
Antimicrob Agents Chemother. 1990 Mar;34(3):487-8. doi: 10.1128/AAC.34.3.487.

本文引用的文献

1
Azlocillin in respiratory tract infections with Pseudomonas aeruginosa in children with cystic fibrosis.阿洛西林用于囊性纤维化患儿铜绿假单胞菌所致的呼吸道感染
Chemotherapy. 1980;26(2):135-40. doi: 10.1159/000237895.
2
Azlocillin with and without an aminoglycoside against respiratory tract infections in children with cystic fibrosis.阿洛西林联合或不联合氨基糖苷类药物治疗囊性纤维化患儿的呼吸道感染。
Scand J Infect Dis Suppl. 1981;29:92-7.
3
In vitro activity of azthreonam, a monobactam antibiotic.单环β-内酰胺类抗生素氨曲南的体外活性
Antimicrob Agents Chemother. 1982 Nov;22(5):832-8. doi: 10.1128/AAC.22.5.832.
4
Activities of various beta-lactams and aminoglycosides, alone and in combination, against isolates of Pseudomonas aeruginosa from patients with cystic fibrosis.多种β-内酰胺类药物和氨基糖苷类药物单独及联合使用时，对囊性纤维化患者分离出的铜绿假单胞菌菌株的活性。
Antimicrob Agents Chemother. 1982 Jun;21(6):939-43. doi: 10.1128/AAC.21.6.939.
5
In vitro activities of aztreonam, piperacillin, and ticarcillin combined with amikacin against amikacin-resistant Pseudomonas aeruginosa and P. cepacia isolates from children with cystic fibrosis.氨曲南、哌拉西林和替卡西林联合阿米卡星对来自囊性纤维化患儿的耐阿米卡星铜绿假单胞菌和洋葱伯克霍尔德菌分离株的体外活性。
Antimicrob Agents Chemother. 1984 Feb;25(2):279-80. doi: 10.1128/AAC.25.2.279.
6
Antibiotic treatment of chronic Pseudomonas aeruginosa infection in cystic fibrosis patients.囊性纤维化患者慢性铜绿假单胞菌感染的抗生素治疗
Scand J Infect Dis Suppl. 1981;29:87-91.
7
Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosis.头孢他啶治疗囊性纤维化患者慢性铜绿假单胞菌呼吸道感染
J Antimicrob Chemother. 1983 Jul;12 Suppl A:313-23. doi: 10.1093/jac/12.suppl_a.313.
8
Clinical and bacteriological responses to three antibiotic regimens for acute exacerbations of cystic fibrosis: ticarcillin-tobramycin, azlocillin-tobramycin, and azlocillin-placebo.三种抗生素治疗方案对囊性纤维化急性加重期的临床及细菌学反应：替卡西林-妥布霉素、阿洛西林-妥布霉素及阿洛西林-安慰剂。
J Infect Dis. 1983 Mar;147(3):559-67. doi: 10.1093/infdis/147.3.559.
9
Activities of new beta-lactam antibiotics against isolates of Pseudomonas aeruginosa from patients with cystic fibrosis.新型β-内酰胺类抗生素对囊性纤维化患者铜绿假单胞菌分离株的活性。
Antimicrob Agents Chemother. 1981 Oct;20(4):545-6. doi: 10.1128/AAC.20.4.545.
10
Carbenicillin and gentamicin: pharmacologic studies in patients with cystic fibrosis and pseudomonas pulmonary infections.羧苄青霉素和庆大霉素：对囊性纤维化和铜绿假单胞菌肺部感染患者的药理学研究
J Pediatr. 1971 Nov;79(5):822-8. doi: 10.1016/s0022-3476(71)80401-8.

氨曲南联合妥布霉素和庆大霉素对囊性纤维化患者铜绿假单胞菌和洋葱伯克霍尔德菌临床分离株的体外活性。

In vitro activity of aztreonam combined with tobramycin and gentamicin against clinical isolates of Pseudomonas aeruginosa and Pseudomonas cepacia from patients with cystic fibrosis.

作者信息

Bosso J A, Saxon B A, Matsen J M

机构信息

Department of Pharmacy Practice, College of Pharmacy, University of Utah, Salt Lake City 84112.

出版信息

Antimicrob Agents Chemother. 1987 Sep;31(9):1403-5. doi: 10.1128/AAC.31.9.1403.

DOI:10.1128/AAC.31.9.1403
PMID:3118798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174950/
Abstract

The in vitro activity of aztreonam combined with tobramycin and with gentamicin was assessed in 78 clinical isolates of Pseudomonas aeruginosa and 11 clinical isolates of Pseudomonas cepacia from patients with cystic fibrosis. Synergy was detected in 56.4% of P. aeruginosa isolates and 60% of P. cepacia isolates with the aztreonam-tobramycin combination and in 49.3% of P. aeruginosa isolates and 81.8% of P. cepacia isolates with the aztreonam-gentamicin combination. No antagonism was observed. These combinations merit clinical evaluation in the treatment of patients with cystic fibrosis.

摘要

对78株来自囊性纤维化患者的铜绿假单胞菌临床分离株和11株洋葱伯克霍尔德菌临床分离株，评估了氨曲南联合妥布霉素以及联合庆大霉素的体外活性。氨曲南 - 妥布霉素联合用药时，在56.4%的铜绿假单胞菌分离株和60%的洋葱伯克霍尔德菌分离株中检测到协同作用；氨曲南 - 庆大霉素联合用药时，在49.3%的铜绿假单胞菌分离株和81.8%的洋葱伯克霍尔德菌分离株中检测到协同作用。未观察到拮抗作用。这些联合用药值得在囊性纤维化患者的治疗中进行临床评估。