神经元视网膜和色素上皮移植的免疫生物学及免疫赦免

Immunobiology and privilege of neuronal retina and pigment epithelium transplants.

作者信息

Streilein J Wayne, Ma Naili, Wenkel Hartmut, Ng Tat Fong, Zamiri Parisa

机构信息

Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA.

出版信息

Vision Res. 2002 Feb;42(4):487-95. doi: 10.1016/s0042-6989(01)00185-7.

DOI:10.1016/s0042-6989(01)00185-7

PMID:11853765

Abstract

Despite the existence of ocular immune privilege, immune rejection may be a barrier to successful retinal transplantation. We have examined in mice the extent to which the subretinal space (SRS) is an immune privileged site, and whether retinal pigment epithelium and neuronal retinal tissue have properties of immune privileged tissues. We report that (1) The SRS is an immune privileged site; (2) Neonatal RPE is an immune privileged tissue; (3) Neuronal retina is a partially immune privileged tissue; and (4) Microglia within neonatal neural retina grafts promote photoreceptor differentiation, become activated, and induce sensitization of the recipient and serve as targets of immune rejection.

摘要

尽管存在眼免疫赦免，但免疫排斥可能是视网膜移植成功的一个障碍。我们已在小鼠中研究了视网膜下间隙（SRS）作为免疫赦免部位的程度，以及视网膜色素上皮和神经视网膜组织是否具有免疫赦免组织的特性。我们报告：（1）SRS是一个免疫赦免部位；（2）新生视网膜色素上皮是一种免疫赦免组织；（3）神经视网膜是一种部分免疫赦免组织；（4）新生神经视网膜移植物中的小胶质细胞促进光感受器分化，被激活，并诱导受体致敏，且作为免疫排斥的靶点。