Taylor Andrew W, Hsu Samuel, Ng Tat Fong
Department of Ophthalmology, Boston University School of Medicine, Boston, MA, United States.
Front Immunol. 2021 Aug 13;12:724601. doi: 10.3389/fimmu.2021.724601. eCollection 2021.
The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cells (RPE) regulate the activity of immune cells within the retina. These mechanisms involve the expression of immunomodulating molecules that make macrophages and microglial cells suppress inflammation and promote immune tolerance. The RPE have an important role in ocular immune privilege to regulate the behavior of immune cells within the retina. Reviewed is the current understanding of how RPE mediate this regulation and the changes seen under pathological conditions.
眼部组织微环境具有免疫赦免特性，并利用多种免疫抑制机制来防止炎症的诱导。视网膜色素上皮细胞（RPE）除了作为血视网膜屏障和光感受器营养物质的来源外，还调节视网膜内免疫细胞的活性。这些机制涉及免疫调节分子的表达，这些分子可使巨噬细胞和小胶质细胞抑制炎症并促进免疫耐受。RPE在眼部免疫赦免中起着重要作用，以调节视网膜内免疫细胞的行为。本文综述了目前对RPE如何介导这种调节以及在病理条件下所观察到的变化的理解。
