Saha M R, Saha D, Dutta P, Mitra U, Bhattacharya S K
National Institute of Cholera and Enteric Diseases, P-33, CIT Road, Scheme XM, Beliaghata, Calcutta 700 010, West Bengal, India.
J Health Popul Nutr. 2001 Dec;19(4):301-5.
The prevalence of Salmonella enterica serotypes, antimicrobial susceptibility, and phage typing of serovers were studied. Clinical presentations of the infected cases were also examined. The study was carried out during August 1993-September 1996 in and around Calcutta, India. In total, 1,025 faecal samples from hospitalized diarrhoeal children were screened for enteropathogens. Four S. enterica serotypes were identified in 157 (15.3%) cases as a single pathogen. S. enterica serotype Typhimurium was detected in 110 (70%) cases. S. Seftenberg, S. Infantis, and S. Virchow were detected in 28 (17.8%), 14 (8.9%), and 5 (3.2%) cases respectively. S. Typhimurium was isolated from 11 (3.2%) non-diarrhoeal control children. All of these children had acute watery diarrhoea, and 5% of them had severe dehydration, 40% had some dehydration, and 55% had no dehydration. Vomiting, fever, and diffused pain in abdomen were the associated presentations of these children. Most (95%) of them recovered with oral rehydration therapy only and without any antibiotics. In-vitro susceptibility testing showed that 120 of the 121 S. Typhimurium strains isolated from cases and controls were resistant to the commonly-used drugs. Thirteen of the 121 strains were phage-typeable and belonged to the phage type 193. However, no clinical or epidemiological significance could be established with these typeable strains. The findings of the study indicate that diarrhoeagenic Salmonella is one of the major pathogens causing diarrhoeal diseases in eastern India.
对肠炎沙门氏菌血清型的流行情况、抗菌药敏性以及血清型的噬菌体分型进行了研究。还对感染病例的临床表现进行了检查。该研究于1993年8月至1996年9月在印度加尔各答及其周边地区开展。总共对1025份来自住院腹泻儿童的粪便样本进行了肠道病原体筛查。在157例（15.3%）病例中鉴定出四种肠炎沙门氏菌血清型为单一病原体。在110例（70%）病例中检测到鼠伤寒沙门氏菌血清型。分别在28例（17.8%）、14例（8.9%）和5例（3.2%）病例中检测到斯坦利沙门氏菌、婴儿沙门氏菌和维尔肖沙门氏菌。从11例（3.2%）非腹泻对照儿童中分离出鼠伤寒沙门氏菌。所有这些儿童均患有急性水样腹泻，其中5%有严重脱水，40%有轻度脱水，55%无脱水。呕吐、发热和腹部弥漫性疼痛是这些儿童的相关表现。大多数（95%）儿童仅通过口服补液疗法即可康复，无需使用任何抗生素。体外药敏试验表明，从病例和对照中分离出的121株鼠伤寒沙门氏菌中有120株对常用药物耐药。121株菌株中有13株可进行噬菌体分型，属于噬菌体193型。然而，这些可分型菌株的临床或流行病学意义无法确定。该研究结果表明，致腹泻性沙门氏菌是印度东部引起腹泻疾病的主要病原体之一。
