Niedermayer A O, Koski R G
J Pharm Sci. 1975 Sep;64(9):1531-4. doi: 10.1002/jps.2600640924.
This report describes the isolation, derivative formation, GLC, and quantitation of unmetabolized 7-chloro-5,11-dihydrodibenz[b,e][1,4]oxazepine-5-carboxamide (I) in blood serum or plasma. Carbamazepine is used as the internal standard to compensate for losses of I during extraction and handling. Essentially complete recovery (100 +/- 6%) was demonstrated over a concentration range of 1-30 mug of I/ml of serum.
本报告描述了血清或血浆中未代谢的7-氯-5,11-二氢二苯并[b,e][1,4]恶唑并氮杂卓-5-甲酰胺（I）的分离、衍生物形成、气相色谱分析及定量。卡马西平用作内标，以补偿I在提取和处理过程中的损失。在I浓度为1 - 30μg/ml血清的范围内，回收率基本完全（100±6%）。
