Critchley Hugo D, Mathias Christopher J, Dolan Raymond J
Wellcome Department of Imaging Neuroscience, 12 Queen Square, Institute of Neurology and Institute of Cognitive Neuroscience, UCL, WC1N 3BG, London, United Kingdom.
Neuron. 2002 Feb 14;33(4):653-63. doi: 10.1016/s0896-6273(02)00588-3.
The degree to which perceptual awareness of threat stimuli and bodily states of arousal modulates neural activity associated with fear conditioning is unknown. We used functional magnetic neuroimaging (fMRI) to study healthy subjects and patients with peripheral autonomic denervation to examine how the expression of conditioning-related activity is modulated by stimulus awareness and autonomic arousal. In controls, enhanced amygdala activity was evident during conditioning to both "seen" (unmasked) and "unseen" (backward masked) stimuli, whereas insula activity was modulated by perceptual awareness of a threat stimulus. Absent peripheral autonomic arousal, in patients with autonomic denervation, was associated with decreased conditioning-related activity in insula and amygdala. The findings indicate that the expression of conditioning-related neural activity is modulated by both awareness and representations of bodily states of autonomic arousal.
威胁刺激的感知意识和身体唤醒状态对与恐惧条件作用相关的神经活动的调节程度尚不清楚。我们使用功能磁共振神经成像（fMRI）来研究健康受试者和外周自主神经去神经支配的患者，以检查条件作用相关活动的表达如何受到刺激意识和自主唤醒的调节。在对照组中，杏仁核活动在对“可见”（未掩蔽）和“不可见”（逆向掩蔽）刺激进行条件作用时均增强，而脑岛活动则受到威胁刺激的感知意识的调节。自主神经去神经支配的患者缺乏外周自主唤醒，这与脑岛和杏仁核中条件作用相关活动的减少有关。这些发现表明，条件作用相关神经活动的表达受到自主唤醒身体状态的意识和表征的调节。
