与疲劳小鼠肌肉舒张减慢相关的代谢变化。
Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.
作者信息
Edwards R H, Hill D K, Jones D A
出版信息
J Physiol. 1975 Oct;251(2):287-301. doi: 10.1113/jphysiol.1975.sp011093.
Abstract
- The biochemical basis of the slowing of relaxation seen in fatigue has been examined using an isolated mouse soleus preparation. 2. Slowing of relaxation occurred during prolonged tetani under anaerobic conditions when ATP and PC fell and lactate accumulated. 3. Slowing of relaxation was also demonstrated with muscles poisoned with cyanide and iodoacetic acid when there was a fall in ATP and PC but no accumulation of lactate. During a period of anaerobic recovery following a fatiguing tetanus, relaxation became faster at a time when lactate was accumulating in the muscle. 4. It is concluded that the slowing of relaxation in fatigue is not a consequence of lactate accumulation, and a relationship is demonstrated between the ATP content of the muscle and the rate of relaxation in muscles fatigued by prolonged stimulation, 5. Rates of ATP turn-over in fresh muscle, and at intervals throughout a tetanus are consistent with the suggestion that the rate limiting step for myofibrillar ATPase may be directly related to the rate limiting step for the decay of tension during relaxation.
摘要
- 利用分离的小鼠比目鱼肌标本，研究了疲劳时出现的舒张减慢的生化基础。2. 在无氧条件下长时间强直收缩期间，当三磷酸腺苷（ATP）和磷酸肌酸（PC）含量下降且乳酸积累时，出现舒张减慢。3. 当肌肉用氰化物和碘乙酸中毒时，尽管ATP和PC含量下降但无乳酸积累，也证实了舒张减慢。在疲劳性强直收缩后的无氧恢复期间，当肌肉中乳酸积累时，舒张变得更快。4. 得出结论，疲劳时舒张减慢不是乳酸积累的结果，并且证明了肌肉的ATP含量与长时间刺激疲劳的肌肉的舒张速率之间存在关系。5. 新鲜肌肉以及强直收缩过程中不同时间点的ATP周转速率与以下观点一致，即肌原纤维ATP酶的限速步骤可能与舒张过程中张力衰减的限速步骤直接相关。
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