Manuel-y-Keenoy B, Nonneman L, De Bosscher H, Vertommen J, Schrans S, Klütsch K, De Leeuw I
Laboratory of Endocrinology, University Hospital, University of Antwerp, Antwerp, Belgium.
Eur J Clin Nutr. 2002 Feb;56(2):121-8. doi: 10.1038/sj.ejcn.1601294.
To compare the effects of a lipid emulsion containing medium-chain triglycerides (MCT) and supplemented with alpha-tocopherol to a conventional long-chain triglyceride (LCT) emulsion.
Randomised double blind study.
Department of Internal Medicine, Antwerp University Hospital.
Twenty-four patients with an indication for total parenteral nutrition for a minimum of 10 days were randomly assigned to two groups: group E received as lipid source MCT/LCT (50/50) suplemented with 100 mg DL-alpha-tocopherol/day and group C received LCT. Blood samples were analysed at inclusion, after 4-6 and after 9-11 days.
In group E, serum alpha-tocopherol doubled from 11.4+/-6.9 at inclusion to 20.9+/-7.9 and to 23.8+/-8.8 microg/ml after 4 and 9 days, respectively, but did not change in group C (P=0.008). Production of thiobarbituric acid-reacting substances (TBARS) after 120 min incubation with copper decreased from 66+/-34 at inclusion to 29+/-25 nmol MDA/mg LDL and VLDL-cholesterol after 4 and to 42+/-17 after 9 days (P=0.022 when compared to group C, which underwent no significant changes). Velocity of production of fluorescent products decreased in group E but not in group C (P=0.026).
Supplementation of TPN containing MCT/LCT with 100 mg DL-alpha-tocopherol/day leads to a doubling in serum alpha-tocopherol and to a decrease in the susceptibility of LDL and VLDL to peroxidation in vitro.
This study was partly financed by B Braun Medical NVSA, Diegem, Belgium.
比较含中链甘油三酯（MCT）并补充了α-生育酚的脂质乳剂与传统长链甘油三酯（LCT）乳剂的效果。
随机双盲研究。
安特卫普大学医院内科。
24例有全肠外营养指征且至少需要10天的患者被随机分为两组：E组接受MCT/LCT（50/50）作为脂质来源，并每日补充100mg DL-α-生育酚；C组接受LCT。在入组时、4 - 6天后以及9 - 11天后采集血样进行分析。
E组血清α-生育酚在入组时为11.4±6.9μg/ml，4天后翻倍至20.9±7.9μg/ml，9天后进一步升至23.8±8.8μg/ml，而C组无变化（P = 0.008）。与铜孵育120分钟后硫代巴比妥酸反应物质（TBARS）的生成量，E组入组时为66±34nmol MDA/mg LDL和VLDL胆固醇，4天后降至29±25，9天后降至42±17（与无显著变化的C组相比，P = 0.022）。E组荧光产物生成速度下降，C组则未下降（P = 0.026）。
每日在含MCT/LCT的全肠外营养中补充100mg DL-α-生育酚可使血清α-生育酚翻倍，并降低体外LDL和VLDL的过氧化敏感性。
本研究部分由比利时迪耶姆的贝朗医疗NVSA资助。
