Lépine François, Milot S, Zamir L, Morel R
Centre de Microbiologie et Biotechnologie, INRS-Institut Armand-Frappier, Université du Québec, 531 desPrairies blvd, Laval, Québec H7V 1B7, Canada.
J Mass Spectrom. 2002 Feb;37(2):216-22. doi: 10.1002/jms.277.
Four alkaloids were isolated from an alcoholic extract of the bark from the stem of Peschiera fuschiaefolia. Two of these compounds, voacamine and voacamidine, are dimeric alkaloids which are thought to be responsible for the antimalarial activity of these extracts. The mass spectra and the response factors of these four compounds were obtained by liquid chromatography/mass spectrometry in the electrospray positive ionization mode. The concentrations of these alkaloids were measured in two different P. fuschiaefolia extracts. The ion chromatograms of the two extracts were compared on the basis of their M + H and M + 2H ions characteristic of various alkaloids previously isolated from P. fuschiaefolia bark. The two extracts were found to differ mostly in the relative concentrations of the dimeric alkaloids.
