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Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse.

作者信息

Higashi Yujiro, Maruhashi Mitsuji, Nelles Luc, Van de Putte Tom, Verschueren Kristin, Miyoshi Tomoya, Yoshimoto Aki, Kondoh Hisato, Huylebroeck Danny

机构信息

Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Osaka, Japan.

出版信息

Genesis. 2002 Feb;32(2):82-4. doi: 10.1002/gene.10048.

DOI:10.1002/gene.10048
PMID:11857784
Abstract
摘要

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1
Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse.用于在小鼠中进行Cre介导的条件性敲除的SIP1（Smad相互作用蛋白1）基因的floxed等位基因的产生。
Genesis. 2002 Feb;32(2):82-4. doi: 10.1002/gene.10048.
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Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome.缺乏ZFHX1B（编码与Smad相互作用蛋白-1的基因）的小鼠揭示了多种神经嵴细胞缺陷在先天性巨结肠-智力发育迟缓综合征病因学中的作用。
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New mode of DNA binding of multi-zinc finger transcription factors: deltaEF1 family members bind with two hands to two target sites.多锌指转录因子DNA结合的新模式：δEF1家族成员用双手结合两个靶位点。
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SIP1 (Smad interacting protein 1) and deltaEF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors.SIP1（Smad相互作用蛋白1）和deltaEF1（δ-晶体蛋白增强子结合因子）是结构相似的转录抑制因子。
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Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.Balancer-Cre转基因小鼠生殖细胞导致三loxP靶向的Cyp1a1等位基因的不完全解析，产生一个条件性敲除等位基因。
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Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development.在鸡和小鼠妊娠中期肢体发育过程中，Zfhx1a和Zfhx1b信使核糖核酸具有不重叠的表达域。
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Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease.编码Smad相互作用蛋白1的SIP1发生突变会导致一种先天性巨结肠症。
Nat Genet. 2001 Apr;27(4):369-70. doi: 10.1038/86860.

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