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Generation of a conditionally null allele of hnf4alpha.

作者信息

Parviz Fereshteh, Li Jixuan, Kaestner Klaus H, Duncan Stephen A

机构信息

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

出版信息

Genesis. 2002 Feb;32(2):130-3. doi: 10.1002/gene.10058.

DOI:10.1002/gene.10058
PMID:11857799
Abstract
摘要

相似文献

1
Generation of a conditionally null allele of hnf4alpha.肝细胞核因子4α（hnf4α）条件性无效等位基因的产生。
Genesis. 2002 Feb;32(2):130-3. doi: 10.1002/gene.10058.
2
Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo.携带肝特异性肝细胞转录因子4α（HNF4α）缺失的小鼠尿素生成缺陷。HNF4α在体内调节鸟氨酸转氨甲酰酶。
J Biol Chem. 2002 Jul 12;277(28):25257-65. doi: 10.1074/jbc.M203126200. Epub 2002 May 6.
3
HNF4: a central regulator of hepatocyte differentiation and function.肝细胞核因子4：肝细胞分化与功能的核心调节因子
Hepatology. 2003 Jun;37(6):1249-53. doi: 10.1053/jhep.2003.50273.
4
Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development.肝细胞核因子4α在胎儿肝脏发育过程中对孕烷X受体的调控作用。
Hepatology. 2003 Jun;37(6):1375-84. doi: 10.1053/jhep.2003.50212.
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The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.孤儿核受体HNF4α决定了PXR和CAR介导的CYP3A4的异生素诱导作用。
Nat Med. 2003 Feb;9(2):220-4. doi: 10.1038/nm815. Epub 2003 Jan 6.
6
Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity.配体结合结构域螺旋7中的带电残基在肝细胞核因子4α二聚化和转录活性中的关键作用。
Nucleic Acids Res. 2003 Nov 15;31(22):6640-50. doi: 10.1093/nar/gkg850.
7
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.肝细胞核因子4α（核受体2A1）对于维持肝脏基因表达和脂质稳态至关重要。
Mol Cell Biol. 2001 Feb;21(4):1393-403. doi: 10.1128/MCB.21.4.1393-1403.2001.
8
Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator.年轻成年发病型糖尿病1型（MODY1）相关突变，即肝细胞核因子4α（HNF4α）基因中的R154X和E276Q，会损害关键转录共激活因子p300的募集。
Mol Endocrinol. 2001 Jul;15(7):1200-10. doi: 10.1210/mend.15.7.0670.
9
Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.人类HNF4α基因中自然发生的突变会不同程度地损害转录因子的功能。
Nucleic Acids Res. 2000 Jan 15;28(2):430-7. doi: 10.1093/nar/28.2.430.
10
The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.CYP2D6人源化小鼠：人CYP2D6转基因和肝细胞核因子4α对小鼠体内异喹胍处置的影响
Mol Pharmacol. 2001 Dec;60(6):1260-7. doi: 10.1124/mol.60.6.1260.

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Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development.在小鼠肾脏发育过程中，近端小管细胞对髓袢细降支有贡献。
bioRxiv. 2025 Mar 24:2025.01.14.633065. doi: 10.1101/2025.01.14.633065.
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Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.肝细胞核因子 4α 介导的喹啉酸磷酸核糖基转移酶（QPRT）在肾脏中的表达有助于抵抗急性肾损伤。
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Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus.
Hnf4 激活模拟细胞增强子，在胸腺内再现肠道和肝脏的发育。
J Exp Med. 2023 Oct 2;220(10). doi: 10.1084/jem.20230461. Epub 2023 Jul 3.
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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A.HASTER lncRNA 启动子是 HNF1A 的顺式作用转录稳定剂。
Nat Cell Biol. 2022 Oct;24(10):1528-1540. doi: 10.1038/s41556-022-00996-8. Epub 2022 Oct 6.
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Hnf4a Is Required for the Development of Cdh6-Expressing Progenitors into Proximal Tubules in the Mouse Kidney.Hnf4a 对于将 Cd h6 表达祖细胞发育为小鼠肾脏近曲小管是必需的。
J Am Soc Nephrol. 2020 Nov;31(11):2543-2558. doi: 10.1681/ASN.2020020184. Epub 2020 Aug 6.
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Collapse of the hepatic gene regulatory network in the absence of FoxA factors.FoxA 因子缺失时肝基因调控网络的崩溃。
Genes Dev. 2020 Aug 1;34(15-16):1039-1050. doi: 10.1101/gad.337691.120. Epub 2020 Jun 19.
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Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.小鼠肾脏中 Hnf4a 的缺失可模拟法布里肾 tubular 综合征。
JCI Insight. 2018 Jul 26;3(14). doi: 10.1172/jci.insight.97497.
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eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.在接受高果糖饮食挑战的小鼠中，eIF2α磷酸化是预防肝细胞死亡和肝纤维化所必需的。
Nutr Metab (Lond). 2017 Aug 1;14:48. doi: 10.1186/s12986-017-0202-6. eCollection 2017.
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The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light.去泛素化酶 USP2 与生物钟有关，并调节其对光的敏感性。
PLoS One. 2011;6(9):e25382. doi: 10.1371/journal.pone.0025382. Epub 2011 Sep 23.
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Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H.肝细胞核因子4α通过调节环磷酸腺苷反应元件结合蛋白H的表达参与内质网应激诱导的急性期反应。
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