Saji H, Hosoi T
Vox Sang. 1979;37(5):296-304. doi: 10.1111/j.1423-0410.1979.tb02308.x.
This report describes a Japanese family have two Rhmod members, and two sibs with slightly depressed Rh antigens. It is proposed that the Rhmod and the depressed Rh antigen phenotypes are due to regulator genes in homozygous or heterozygous condition, respectively. The two Rhmod members showed mild reticulocytosis, stomatocytosis, slight anisocytosis, slight hyperchromia and slight punctate basophilia without anaemia. Scanning electron microscopy showed their red cells to be small and of bowl shape. Increased fragility of their erythrocytes was demonstrated by dynamic osmofragility testing using a coil planet centrifuge.
本报告描述了一个日本家庭，其中有两名Rhmod成员，以及两名Rh抗原略低的同胞。有人提出，Rhmod和Rh抗原降低的表型分别是由于纯合或杂合状态的调节基因所致。两名Rhmod成员表现出轻度的网织红细胞增多、口形红细胞增多、轻度的红细胞大小不均、轻度的红细胞着色过深和轻度的点彩嗜碱性粒细胞增多，但无贫血。扫描电子显微镜显示他们的红细胞较小，呈碗状。使用盘管行星离心机进行的动态渗透脆性试验证明了他们的红细胞脆性增加。
