Roeters van Lennep Jeanine E, Westerveld H Tineke, Erkelens D Willem, van der Wall Ernst E
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Cardiovasc Res. 2002 Feb 15;53(3):538-49. doi: 10.1016/s0008-6363(01)00388-1.
It has been recognized over the past years that women form a distinct subpopulation within patients with coronary heart disease. This phenomenon should be acknowledged in the management and in the assessment of coronary heart disease. Over the past years remarkable progress has been made concerning our knowledge of cardiovascular risk factors related to gender. For instance, diabetes, high density lipoproteins and triglycerides levels have been found to have a greater impact on coronary heart disease risk in women compared to men. On the other hand, evidence showing that lipoprotein (a) is a cardiovascular risk factor seems to be stronger in men than in women. For optimal treatment and prevention of coronary heart disease it is necessary to acknowledge that it is not self-evident that women and men show similar responses to risk factors or to treatment. This review article addresses the role of cardiovascular risk factors focusing on the differential impact they might have on men and women.
在过去几年中，人们已经认识到女性在冠心病患者中构成了一个独特的亚群体。在冠心病的管理和评估中应认识到这一现象。在过去几年里，我们对与性别相关的心血管危险因素的认识取得了显著进展。例如，已发现糖尿病、高密度脂蛋白和甘油三酯水平对女性冠心病风险的影响比对男性更大。另一方面，脂蛋白(a)是心血管危险因素的证据在男性中似乎比在女性中更强。为了对冠心病进行最佳治疗和预防，有必要认识到，男性和女性对危险因素或治疗的反应并非不言而喻地相似。这篇综述文章探讨了心血管危险因素的作用，重点关注它们可能对男性和女性产生的不同影响。
