Fisher E R, Shoemaker R H, Palekar A S
Lab Invest. 1975 Oct;33(4):446-50.
Mammary lobuloalveolar hyperplasia induced in rats by the administration of estradiol or progesterone did not evolve into advanced hyperplasia or cancer as was noted in animals that received these hormones and peroral instillations of methylcholanthrene. Although the early hyperplastic changes encountered in both groups were histologically indistinguishable, only cells from the lesions of the rats treated with methylcholanthrene and hormones exhibited significant numbers of aneuploid cells. This information indicates that, at least in the rat, not all instances of mammary hyperplasia possess the potential to develop into cancer. Chromosome analysis appears to represent a useful technique for the discrimination of these forms of hyperplasia. The significance of an appropriate inducer, i.e., methylcholanthrene, for the development of mammary carcinoma in this model system, as well as the well recognized proper hormonal milieu, is apparent.
通过给予雌二醇或孕酮在大鼠中诱导产生的乳腺小叶腺泡增生，并未发展为高级别增生或癌症，这与接受这些激素并经口滴注甲基胆蒽的动物情况不同。尽管两组中早期增生性改变在组织学上难以区分，但仅来自经甲基胆蒽和激素处理的大鼠病变中的细胞显示出大量非整倍体细胞。该信息表明，至少在大鼠中，并非所有乳腺增生实例都具有发展为癌症的潜力。染色体分析似乎是区分这些增生形式的有用技术。在该模型系统中，合适的诱导剂即甲基胆蒽对于乳腺癌发生的重要性，以及广为人知的适当激素环境，是显而易见的。
