Kawasaki K, Nishijima M
Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Jpn J Infect Dis. 2001 Dec;54(6):220-4.
Recognition of bacterial envelope constituents is one mechanism used by mammalian cells to initiate responses leading to bacterial killing, or, unfortunately, responses that also cause fatal septic shock. Many cell surface receptors by which these microbial components are recognized have been identified and characterized over the past a few years. In addition to CD14, which has been shown to be involved in the recognition of many microbial components, Toll-like receptors and MD-2 have been identified as factors playing a role in the receptor complexes of these components. Here we review the recent findings regarding the molecular basis for the recognition of microbial components.
识别细菌包膜成分是哺乳动物细胞用于引发导致细菌杀伤反应的一种机制，或者不幸的是，也是引发导致致命性脓毒症休克反应的一种机制。在过去几年里，许多识别这些微生物成分的细胞表面受体已被鉴定和表征。除了已被证明参与识别许多微生物成分的CD14外，Toll样受体和MD-2也已被确定为在这些成分的受体复合物中发挥作用的因子。在此，我们综述了有关微生物成分识别分子基础的最新研究结果。
