Baykal Can, Büyükbabani Nesimi, Kavak Ayse, Alper Murat
Department of Dermatology, Istanbul University, Istanbul Medical School, 34390-Capa, Istanbul, Turkey.
J Am Acad Dermatol. 2002 Mar;46(3):414-8. doi: 10.1067/mjd.2002.119646.
Although nevoid hyperkeratosis of the nipple and areola was initially described in 1923, there are only case reports or reviews about it; no large series have been documented to date. The clinical features of the reported cases in the literature are not uniform, and it is questioned whether nevoid hyperkeratosis of the nipple and areola is a distinct clinicopathologic entity or a clinical presentation of various dermatoses. We describe 7 cases with hyperkeratotic nevoid lesions localized on the nipple and areola with different clinical features. None of them had any other associated dermatologic or systemic disease. Histopathologic examination was performed in 6 patients. Four of them had common histopathologic features suggesting a distinct entity, namely, nevoid hyperkeratosis of the nipple and areola; 2 of them had histopathologic features consistent with seborrheic keratosis. Seborrheic keratosis presents as sharply demarcated papules or plaques, whereas nevoid hyperkeratosis of the nipple or areola presents as a plaque diffusely involving the nipple or the areola.
尽管乳头乳晕痣样角化病最初于1923年被描述，但关于它的报道仅有病例报告或综述；迄今为止尚无大量病例系列的记录。文献中报道病例的临床特征并不一致，乳头乳晕痣样角化病究竟是一种独特的临床病理实体还是各种皮肤病的一种临床表现也受到质疑。我们描述了7例乳头乳晕出现角化性痣样损害且具有不同临床特征的病例。他们均无其他相关的皮肤或系统性疾病。6例患者进行了组织病理学检查。其中4例具有提示一种独特实体（即乳头乳晕痣样角化病）的共同组织病理学特征；2例具有与脂溢性角化病一致的组织病理学特征。脂溢性角化病表现为边界清晰的丘疹或斑块，而乳头或乳晕的痣样角化病表现为弥漫累及乳头或乳晕的斑块。
