Meechan J G, Parry G, Rattray D T, Thomason J M
Oral and Maxillofacial Surgery, Dental School, University of Newcastle upon Tyne.
Br Dent J. 2002 Feb 9;192(3):161-3. doi: 10.1038/sj.bdj.4801323.
To investigate the cardiovascular responses of cardiac transplant recipients to dental local anaesthetic solutions with and without epinephrine (adrenaline).
A clinical study employing 30 patients (20 cardiac transplant recipients and ten healthy) awaiting gingival or minor oral surgery under local anaesthesia receiving either 4.4 ml lidocaine (lignocaine) with 1:80,000 epinephrine or 4.4 ml 3% prilocaine with 0.031 U/ml felypressin.
Cardiac transplant patients experienced a significant tachycardia 10 minutes after injection of the epinephrine-containing solution. No significant change in heart rate was detected after the injection of an epinephrine-free solution. Blood pressure was not affected. Periodontal surgery did not affect the responses to the local anaesthetics in the transplant recipients.
The cardiovascular response to dental local anaesthesia in cardiac transplant recipients is governed by the solution injected.
研究心脏移植受者对含肾上腺素（肾上腺素）和不含肾上腺素的牙科局部麻醉溶液的心血管反应。
一项临床研究，纳入30例患者（20例心脏移植受者和10例健康者），他们在局部麻醉下等待进行牙龈或小型口腔手术，分别接受4.4毫升含1:80,000肾上腺素的利多卡因（利多卡因）或4.4毫升含0.031 U/ml去氧肾上腺素的3%丙胺卡因。
心脏移植患者在注射含肾上腺素溶液10分钟后出现显著的心动过速。注射不含肾上腺素的溶液后未检测到心率有显著变化。血压未受影响。牙周手术未影响移植受者对局部麻醉剂的反应。
心脏移植受者对牙科局部麻醉的心血管反应取决于所注射的溶液。
