Prim Espada M P, De Diego Sastre J I, Alfonso Carrillo C, Sastre Baticon N
Servicio de Otorrinolaringología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Spain.
An Esp Pediatr. 2002 Mar;56(3):204-7.
A prospective study was designed to assess the most relevant prognostic factors influencing outcome in children treated with antibiotics for recurrent acute otitis media (AOM).
A prospective study was performed in 69 patients with recurrent AOM who received prophylactic treatment in the Pediatric Otorhinolaryngology Section of our hospital between January 1998 and May 1999. In all patients, 17 variables were registered: age, sex, family history of recurrent AOM, history of prematurity, history of allergies, use of day care centers, household smokers, maternal smoking, coincidence with dental eruption, symptoms of upper respiratory obstruction (snoring, breathing through the mouth, obstructive tonsils), episodes of tonsillitis per year, age at first AOM episode, season in which prophylaxis was started, and characteristics of neonatal feeding (breast or bottle feeding and position). ResultsThe mean age was 35.3 months (range: 9-120 months). There were 38 boys (55.1 %) and 31 girls (44.9 %). The factors related to a more favorable response to treatment were lower age at the first AOM episode (p 0.004) and a positive family history of AOM (p 0.047).
The children that benefitted most from the prophylactic schedules for recurrent AOM were those that had the first episode at an earlier age and who had a positive family history of the disease.
设计一项前瞻性研究，以评估影响复发性急性中耳炎（AOM）患儿接受抗生素治疗预后的最相关因素。
对1998年1月至1999年5月在我院小儿耳鼻咽喉科接受预防性治疗的69例复发性AOM患者进行了前瞻性研究。在所有患者中，记录了17个变量：年龄、性别、复发性AOM家族史、早产史、过敏史、日托中心使用情况、家庭吸烟者、母亲吸烟情况、出牙情况、上呼吸道阻塞症状（打鼾、口呼吸、扁桃体肥大）、每年扁桃体炎发作次数、首次AOM发作年龄、开始预防的季节以及新生儿喂养特点（母乳喂养或奶瓶喂养及姿势）。结果平均年龄为35.3个月（范围：9 - 120个月）。有38名男孩（55.1%）和31名女孩（44.9%）。与治疗反应更良好相关的因素是首次AOM发作时年龄较小（p = 0.004）和AOM家族史阳性（p = 0.047）。
从复发性AOM预防性治疗方案中获益最大的儿童是那些首次发作年龄较早且有该病家族史阳性的儿童。
