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Functional peculiarities of MAP2 in DBA/2J inbred mice as a component of genetic predisposition to seizures.

作者信息

Chulanova T A, Echikov S N, Sadovnikov V B, Shchipakina T G

机构信息

Group of the Mechanisms of Synaptic Transmission, Institute of Theoretical and Experimental Biophysics, Pushchino.

出版信息

Bull Exp Biol Med. 2001 Nov;132(5):1058-61. doi: 10.1023/a:1017960306927.

DOI:10.1023/a:1017960306927
PMID:11865321
Abstract

We compared the content of high molecular microtubule-associated protein-2 and its phosphorylation by cAMP- and Ca(2+)/calmodulin-dependent protein kinases in the brain of DBA/2J and C57Bl/6 inbred mice. The revealed differences in protein content and phosphorylation can be attributed to the mechanisms mediating audiogenic seizures in DBA/2J mice and to differential sensitivity of these inbred lines to seizure-inducing factors.

摘要

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