Fushiki Hiroshi, Yuuki Hiroyoshi, Nakashima Akitoshi, Fujimura Masaki, Saito Shigeru, Izumi Rikuichi
Dept. of Obstetrics and Gynecology, Tonami General Hospital.
Gan To Kagaku Ryoho. 2002 Feb;29(2):215-9.
To examine apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer xenografted into nude mice.
The TUNEL method was used to investigate the induction of apoptosis after exposure to anti-cancer drugs in thirteen gynecological cancers xenografted into nude mice. Moreover, in vivo sensitivities of gynecologic cancer to anti-cancer drugs were determined according to the protocol developed by Battle Laboratories, Columbus, Ohio USA. Both methods were examined for correlation.
The apoptosis index by the TUNEL method showed a correlation with the findings using the protocol developed by Battle Laboratories, Columbus, Ohio USA.
Our findings indicate the ability to determine the measure of chemosensitivity by the apoptosis index.
研究凋亡作为裸鼠移植妇科癌症中抗癌药物化学敏感性指标的情况。
采用TUNEL法研究13种裸鼠移植妇科癌症在接触抗癌药物后凋亡的诱导情况。此外，根据美国俄亥俄州哥伦布市巴特尔实验室制定的方案测定妇科癌症对抗癌药物的体内敏感性。对这两种方法进行相关性检验。
TUNEL法检测的凋亡指数与美国俄亥俄州哥伦布市巴特尔实验室制定的方案的检测结果具有相关性。
我们的研究结果表明凋亡指数能够用于测定化学敏感性。
