Xu Z, Yang T, Wu B, Zhong H, Yang Z, Zhou B, Zhang C, Zheng J
Department of Pathology, Health Science Center, Peking University, Beijing 100083, China.
Zhonghua Bing Li Xue Za Zhi. 2001 Dec;30(6):431-3.
To demonstrate that a characteristic SYT-SSX fusion gene resulting from chromosomal translocation t (X; 18) (p11; q11) was detectable in archival paraffin-embedded synovial sarcoma tissues.
SYT-SSX fusion transcripts in 20 synovial sarcomas (histologic subtypes, 15 monophasic and 5 biphasic) were detected and analyzed by the reverse-transcriptase polymerase chain reaction and compared with the results from relevant pathological data.
A specific SYT-SSX RT-PCR product was found in 19 of 20 (95%) synovial sarcomas tested and of the 13 tumors containing SYT-SSX2, 10 were monophasic.
SYT-SSX fusion transcripts are considered as a defining diagnostic marker of synovial sarcomas and the subtypes of SYT-SSX fusion transcripts (SYT-SSX1 and SYT-SSX2) may yield prognostic information.
证实可在存档石蜡包埋的滑膜肉瘤组织中检测到由染色体易位t(X;18)(p11;q11)产生的特征性SYT-SSX融合基因。
通过逆转录聚合酶链反应检测并分析20例滑膜肉瘤（组织学亚型，15例单相型和5例双相型）中的SYT-SSX融合转录本，并与相关病理数据结果进行比较。
在20例检测的滑膜肉瘤中的19例（95%）发现了特异性SYT-SSX逆转录聚合酶链反应产物，在13例含有SYT-SSX2的肿瘤中，10例为单相型。
SYT-SSX融合转录本被认为是滑膜肉瘤的决定性诊断标志物，SYT-SSX融合转录本的亚型（SYT-SSX1和SYT-SSX2）可能产生预后信息。
