Ortuño Jesús, Cuesta Alberto, Rodríguez Alejandro, Esteban M Angeles, Meseguer José
Faculty of Biology, Department of Cell Biology, University of Murcia, 30071, Murcia, Spain.
Vet Immunol Immunopathol. 2002 Feb;85(1-2):41-50. doi: 10.1016/s0165-2427(01)00406-8.
The effects of including lyophilised whole yeast, Saccharomyces cerevisiae, in the diet on the seabream innate immune response were investigated. Gilthead seabream (Sparus aurata L.) specimens were fed four different diets for 4 weeks: a commercial diet as control and the same diet supplemented with 1, 5 or 10 g/kg yeast. After 1, 2 and 4 weeks, serum complement titres, as a humoral parameter, and phagocytic, respiratory burst, myeloperoxidase and natural cytotoxic activities of head-kidney leucocytes, as cellular parameters, were evaluated. The results showed that yeast supplements enhanced all the latter responses, but not the humoral response. This enhancement was dose-dependent except for the cytotoxic activity that was only stimulated by the lower dose of yeast assayed. As yeast cell walls are able to enhance the seabream cellular innate immune response, these results support the possible use of whole yeast as natural inmunostimulants in common fish diets.
研究了在饲料中添加冻干全酵母（酿酒酵母）对鲷鱼先天免疫反应的影响。用四种不同的饲料喂养金头鲷（Sparus aurata L.）标本4周：一种商业饲料作为对照，以及添加了1、5或10 g/kg酵母的相同饲料。在1、2和4周后，评估了作为体液参数的血清补体滴度，以及作为细胞参数的头肾白细胞的吞噬、呼吸爆发、髓过氧化物酶和自然细胞毒性活性。结果表明，酵母补充剂增强了所有后者的反应，但未增强体液反应。这种增强是剂量依赖性的，但细胞毒性活性仅在测定的较低剂量酵母刺激下增强。由于酵母细胞壁能够增强鲷鱼的细胞先天免疫反应，这些结果支持了全酵母作为普通鱼类饲料中天然免疫刺激剂的可能用途。
