Fogarty Linda, Roter Debra, Larson Susan, Burke Jessica, Gillespie Jeanne, Levy Richard
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, USA.
Patient Educ Couns. 2002 Feb;46(2):93-108. doi: 10.1016/s0738-3991(01)00219-1.
A literature search was conducted to collect published articles reporting correlates of HIV medication adherence or interventions designed to increase HIV medication adherence. Proceedings from seven HIV/AIDS-related conferences were searched for relevant abstracts. We found 18 descriptive studies in published articles and 57 in conference proceedings producing over 200 separate variables falling into four broad areas: (1) factors related to treatment regimen; (2) social and psychological factors; (3) institutional resources; and (4) personal attributes. More complex regimens were related to decreased adherence, but were often successfully mitigated by regimen aids. Social and psychological factors reflecting emotional adjustment to HIV/AIDS and provider support were related to adherence. Access to institutional resources was associated with better adherence. Personal attributes showed a mixed relationship; gender was not consistently related to adherence, but younger age, minority status, and a history of substance abuse were often related to non-adherence. The intervention search yielded 16 interventions employing a wide range of behavioral, cognitive and affective strategies. Evidence of effectiveness was weak. We conclude the abstracts are a useful source of information as part of a systematic review, particularly when available published literature is limited, if results and study characteristics are reported in an adequate and standard manner.
进行了文献检索，以收集已发表的报告HIV药物依从性相关因素或旨在提高HIV药物依从性的干预措施的文章。检索了七个与HIV/AIDS相关会议的会议记录以查找相关摘要。我们在已发表文章中发现了18项描述性研究，在会议记录中发现了57项，产生了200多个单独的变量，分为四大类：（1）与治疗方案相关的因素；（2）社会和心理因素；（3）机构资源；（4）个人属性。更复杂的方案与依从性降低有关，但通常通过方案辅助手段成功缓解。反映对HIV/AIDS的情绪调整和提供者支持的社会和心理因素与依从性有关。获得机构资源与更好的依从性相关。个人属性呈现出混合关系；性别与依从性并非始终相关，但年龄较小、少数族裔身份和药物滥用史通常与不依从有关。干预措施检索产生了16项采用广泛行为、认知和情感策略的干预措施。有效性证据薄弱。我们得出结论，作为系统评价的一部分，这些摘要如果以充分和标准的方式报告结果和研究特征，是有用的信息来源，特别是在现有已发表文献有限的情况下。
