Johnson G Allan, Cofer Gary P, Gewalt Sally L, Hedlund Laurence W
Center for In Vivo Microscopy, Duke University Medical Center, Rm 141, D Bryan Neuroscience Bldg, Research Dr, Durham, NC 27710, USA.
Radiology. 2002 Mar;222(3):789-93. doi: 10.1148/radiol.2223010531.
A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isolated organs, at 25-microm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate the method for the evaluation of morphologic phenotype.
一种用于快速形态表型分析的方法通过使用磁共振显微镜得以展示。完整的固定C57BL/6J小鼠以110微米各向同性分辨率成像；完整标本的有限体积以50微米各向同性分辨率成像；分离的器官以25微米各向同性分辨率成像。三维成像技术应用于尿酸酶基因敲除小鼠，以展示评估形态表型的方法。
