Livni N, Laufer A
Pathol Microbiol (Basel). 1975;42(3):159-70. doi: 10.1159/000162736.
Histochemical studies of human breast tumors were performed with particular emphasis on the activity of alkaline phosphatase (AIP), acid phosphatase (AcP) and glucose-6-phosphate dehydrogenase (G6PDH). Enzyme activities in benign and malignant lesions were compared. AIP was prominent in normal mammary epithelium, limited to the myoepithelial layer in benign tumors and was absent in cords of malignant cells. AcP activity was faintly detected in normal mammary epithelium, increased in canalicular epithelium of fibroadenomas and was marked in malignant cells. G6PDH exhibited marked activity in neoplastic epithelium and the stroma of nearly all carcinomas studied, whereas in benign tumors, G6PDH activity was strictly limited to the connective tissue. The study suggests a strong correlation between G6PDH activity and malignancy. The different results obtained by various workers in this field are critically reviewed, and discussed in the light of the results of the present study.
对人类乳腺肿瘤进行了组织化学研究，特别关注碱性磷酸酶（AIP）、酸性磷酸酶（AcP）和葡萄糖-6-磷酸脱氢酶（G6PDH）的活性。比较了良性和恶性病变中的酶活性。AIP在正常乳腺上皮中显著，在良性肿瘤中局限于肌上皮层，而在恶性细胞索中不存在。在正常乳腺上皮中可微弱检测到AcP活性，在纤维腺瘤的小管上皮中增加，在恶性细胞中明显。G6PDH在几乎所有研究的癌的肿瘤上皮和间质中表现出显著活性，而在良性肿瘤中，G6PDH活性严格局限于结缔组织。该研究表明G6PDH活性与恶性肿瘤之间有很强的相关性。对该领域不同研究者获得的不同结果进行了批判性综述，并根据本研究结果进行了讨论。
