Cohen I
Artery. 1979 Mar;5(3):237-45.
Endothelial cell injury is usually followed by the adherence and activation of platelets to exposed subendothelial surfaces. This is then followed by intimal smooth muscle cell proliferation and formation of connective tissue matrix by the smooth muscle cells through synthesis and secretion of collagen, elastic fiber proteins, and proteoglycans, and intracellular and extracellular lipid accumulation. Platelet activation is associated with morphological transformations which lead eventually to the "release reaction". A mitogenic factor has been recently recognized among the substances released from platelets and it may play a crucial role in promoting the intimal proliferation of smooth muscle cells which characterize atherosclerotic plaques.
内皮细胞损伤通常会导致血小板黏附并激活，附着于暴露的内皮下表面。随后，内膜平滑肌细胞增殖，平滑肌细胞通过合成和分泌胶原蛋白、弹性纤维蛋白及蛋白聚糖形成结缔组织基质，同时伴有细胞内和细胞外脂质蓄积。血小板激活与形态学改变相关，最终导致“释放反应”。最近在血小板释放的物质中发现了一种促有丝分裂因子，它可能在促进平滑肌细胞内膜增殖中起关键作用，而平滑肌细胞内膜增殖是动脉粥样硬化斑块的特征。
