甲状腺肿性病变中甲状腺微粒体和甲状腺球蛋白自身抗体的患病率。
Prevalence of thyroid microsomal and thyroglobulin autoantibodies in goitrous lesions.
作者信息
Tayyab M, Bhatti K U, Ditta A
机构信息
Department of Pathology, Postgraduate Medical Institute, King Edward Medical College, Lahore.
出版信息
J Ayub Med Coll Abbottabad. 2001 Jul-Sep;13(3):16-8.
BACKGROUND
This prospective study was done to evaluate the serum levels of Microsomal and Thyroglobulin autoantibodies in patients with toxic diffuse goiter and nodular goitre (non-toxic) undergoing radio-iodine therapy and thyroidectomy respectively.
METHODS
Forty eight patients suffering from thyroid disorders, 29 with nodular goiter and 19 with toxic diffuse goitre (TDG) and 15 age & sex-matched normal controls were studied. Thyroid microsomal (MSAb) and thyroglobulin autoantibodies (TGAb) were estimated in the sera of all the subjects using the commercially available kits based on tanned red cell haemaglutination technique.
RESULTS
MSAb seropositivity in TDG and nodular goitre was found to be 78.9% and 51.7% respectively. On the other hand, TGAb seropositivity was 57.9% and 27.6% in cases of TDG and nodular goitre. 13.3% and 6.7% of the normal controls were positive for MSAb and TGAb respectively.
CONCLUSION
These findings indicate that autoimmunity is implicated in the genesis of commonly occurring thyroid disorders.
背景
本前瞻性研究旨在评估分别接受放射性碘治疗和甲状腺切除术的毒性弥漫性甲状腺肿和结节性甲状腺肿（非毒性）患者的微粒体抗体和甲状腺球蛋白自身抗体的血清水平。
方法
研究了48例甲状腺疾病患者，其中29例为结节性甲状腺肿，19例为毒性弥漫性甲状腺肿（TDG），并选取了15名年龄和性别匹配的正常对照。使用基于鞣酸红细胞血凝技术的市售试剂盒检测所有受试者血清中的甲状腺微粒体抗体（MSAb）和甲状腺球蛋白自身抗体（TGAb）。
结果
发现TDG和结节性甲状腺肿中MSAb血清阳性率分别为78.9%和51.7%。另一方面，TDG和结节性甲状腺肿病例中TGAb血清阳性率分别为57.9%和27.6%。正常对照中MSAb和TGAb的阳性率分别为13.3%和6.7%。
结论
这些发现表明自身免疫与常见甲状腺疾病的发生有关。
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