Ismail M, Janjua M Z
Saidu Medical College, Swat.
J Ayub Med Coll Abbottabad. 2001 Jul-Sep;13(3):7-10.
Exposure during pregnancy to alcohol (ethanol) produces a number of adverse effects. One of them is fetal alcohol syndrome. The hallmark of fetal alcohol syndrome (FAS) is craniofacial dysmorphism and the changes in craniofacial measurement are dependent on the alcoholic dose and its time of exposure. Since prenatal ethanol exposure can alter craniofacial development in rodents and reliably produce long-term behavioral effect in them, the present study was designed to extend the same changes in the Sprague Dawley species.
The albino rat was studied to determine whether gestational exposure to alcohol (Ethanol) produces permanent craniofacial effect. On gestational day (GD7-10) 25% ethanol was injected intraperitoneally to pregnant rats. Various dimensions for skull and face of adult male rats were taken.
Both vertical and coronal dimensions were altered in the exposed animals.
This study demonstrates that exposure to ethanol on a critical gestational period produces permanent craniofacial defects.
孕期接触酒精（乙醇）会产生多种不良影响。其中之一是胎儿酒精综合征。胎儿酒精综合征（FAS）的标志是颅面部畸形，颅面部测量的变化取决于酒精剂量及其接触时间。由于产前乙醇暴露可改变啮齿动物的颅面部发育并在它们身上可靠地产生长期行为影响，本研究旨在在斯普拉格·道利物种中扩展同样的变化。
对白化大鼠进行研究，以确定孕期接触酒精（乙醇）是否会产生永久性颅面部影响。在妊娠第7 - 10天，给怀孕大鼠腹腔注射25%的乙醇。对成年雄性大鼠的颅骨和面部的各个维度进行测量。
暴露组动物的垂直和冠状维度均发生改变。
本研究表明，在关键孕期接触乙醇会产生永久性颅面部缺陷。
