Edwards H G, Dow-Edwards D L
Department of Orthodontics, New York University College of Dentistry, New York 10010.
Teratology. 1991 Oct;44(4):373-8. doi: 10.1002/tera.1420440403.
The rat was studied to determine whether gestational exposure to moderate amounts of ethanol produces permanent craniofacial malformations. Pregnant Long-Evans rats were fed a liquid diet containing 35% ethanol-derived calories or an isocaloric liquid diet between gestation days 6 and 20. Various dimensions of skulls and mandibles from adult male offspring were measured. All measurements taken in the parasagittal and coronal planes were significantly smaller in the ethanol-exposed rats than in the offspring of pair-fed controls. None of the vertical measurements was significantly altered. This report demonstrates that gestational exposure to ethanol in rats, at doses which produce lasting behavioral effects, also produces a specific constellation of craniofacial dysmorphisms without concomitant decreases in body weight.
研究大鼠以确定孕期暴露于适量乙醇是否会导致永久性颅面畸形。在妊娠第6至20天期间，给怀孕的Long-Evans大鼠喂食含35%乙醇热量的液体饮食或等热量液体饮食。测量成年雄性后代颅骨和下颌骨的各种尺寸。乙醇暴露组大鼠矢状旁平面和冠状平面的所有测量值均显著小于配对喂养对照组的后代。垂直测量值均无显著变化。本报告表明，大鼠孕期暴露于产生持久行为影响剂量的乙醇时，也会产生特定的颅面畸形组合，且体重无相应减轻。
