Szylberg T, Harat M, Furtak J
Zakładu Patomorfologii Wojskowego Szpitala Klinicznego SP ZOZ w Bydgoszczy.
Neurol Neurochir Pol. 2001 Sep-Oct;35(5):915-26.
The method is described of multistep pathomorphological examination of biopsy material obtained by stereotactic procedures from brain tumours. In the analysis of 260 biopsies the possibility was assessed of intraoperative cytological examinations confronting the results of these examinations with those of final histological and immunohistochemical investigations. Attention is called to the difficulties in the evaluation of material derived from stereotactic biopsies and to the cause of possible diagnostic errors. It is concluded that the combination of the results of cytological examination of smears and histological examination of paraffin slides makes possible establishing of full pathomorphological diagnosis with determination of tumour type and its malignancy degree in 90.7% of cases. On most cases cytological intraoperative examination had the greatest influence on therapeutic management. In the confrontation of these examinations with histological examinations a high proportion of correct cytological examinations was found (76.6%). Owing to the possibility of application of all techniques of morphological diagnosis, stereotactic biopsy is a reliable method in the diagnosis of brain tumours.
本文描述了对通过立体定向手术从脑肿瘤获取的活检材料进行多步骤病理形态学检查的方法。在对260份活检样本的分析中，评估了术中细胞学检查的可能性，并将这些检查结果与最终的组织学和免疫组织化学研究结果进行对比。文中提请注意评估立体定向活检材料时的困难以及可能出现诊断错误的原因。得出的结论是，涂片细胞学检查结果与石蜡切片组织学检查结果相结合，使得在90.7%的病例中能够确定肿瘤类型及其恶性程度，从而做出完整的病理形态学诊断。在大多数情况下，术中细胞学检查对治疗管理的影响最大。在将这些检查结果与组织学检查结果进行对比时，发现细胞学检查的正确率很高（76.6%）。由于能够应用所有形态学诊断技术，立体定向活检是诊断脑肿瘤的可靠方法。
